Most of the time a finishing putty can be applied over a cured 2K urethane, but it's not without risks, and it shouldn't be done as a normal procedure. If waves large enough to require putty have escaped notice until after 2K is applied, it has to be called an error in judgement that is better off avoided. A lot of the work we do here is not really high end, but we do filler on epoxy and prime and block with epoxy a time or two, applying a bit of finishing putty as needed before going to 2K, just to make sure the work is close enough not to use any more putty.