what type of seam sealer is it? the 2k seam sealers are fine to 2k prime over once it hardens give it a quick scuff..........the 1k stuff, talking urethane here, i have found that you can really only get away with a coat or 2 of primer over it......once you start building up the primer i've seen it start flaking (depends on app of the seam sealer also)......just my experience... i try to use the 2k seam sealer on the exterior panels and the 1k seam sealer, since it is heavier, on inside panels and floors.
epoxy would be a better choice over it though......since the seem sealer stays somewhat flexible.....and the epoxy will stay flexible also.