As Bob pointed out, you should check the tech sheets for what ever product you are using. The sanding base subject was discussed several years ago on another site. Evidently, according to some, some of the other bases contain some kind of "parafin wax" and this can cause a problem if sanded. If there is something that needs to be sanded out, I would not have a problem with doing that, but would spray another coat of base over that area before clearing. Even very fine sanding marks can show up in base if another coat is not applied.
Aaron